ZFIN is now using GRCz12tu for Genomic Data
Gene
rel
- ID
- ZDB-GENE-040718-255
- Name
- v-rel avian reticuloendotheliosis viral oncogene homolog
- Symbol
- rel Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables protein heterodimerization activity. Acts upstream of or within brain development. Predicted to be active in cytoplasm and nucleus. Is expressed in intestine and telencephalon. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human REL (REL proto-oncogene, NF-kB subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Bagheri et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 92 | Alliance | Immunodeficiency 92 | 619652 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR030492 | Rel homology domain, conserved site |
| Domain | IPR002909 | IPT domain |
| Domain | IPR011539 | Rel homology domain, DNA-binding domain |
| Domain | IPR032397 | Rel homology dimerisation domain |
| Domain | IPR033926 | NFkappaB IPT domain |
| Domain | IPR042845 | Proto-oncogene c-Rel, RHD, N-terminal subdomain |
| Family | IPR000451 | NF-kappa-B/Dorsal |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR014756 | Immunoglobulin E-set |
| Homologous_superfamily | IPR037059 | Rel homology domain (RHD), DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin E-set | Immunoglobulin-like fold | IPT domain | NF-kappa-B/Dorsal | NFkappaB IPT domain | p53-like transcription factor, DNA-binding domain superfamily | Proto-oncogene c-Rel, RHD, N-terminal subdomain | Rel homology dimerisation domain | Rel homology domain, conserved site | Rel homology domain, DNA-binding domain | Rel homology domain (RHD), DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6DGE6 | InterPro | 596 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers