ZFIN is now using GRCz12tu for Genomic Data
Gene
crlf1a
- ID
- ZDB-GENE-040718-397
- Name
- cytokine receptor-like factor 1a
- Symbol
- crlf1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable cytokine binding activity and cytokine receptor activity. Predicted to be involved in cytokine-mediated signaling pathway; negative regulation of neuron apoptotic process; and positive regulation of cell population proliferation. Predicted to be part of CRLF-CLCF1 complex and receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in diencephalon; hypothalamus; optic tectum; and telencephalon. Human ortholog(s) of this gene implicated in cold-induced sweating syndrome 1. Orthologous to human CRLF1 (cytokine receptor like factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:91992 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cold-induced sweating syndrome 1 | Alliance | Cold-induced sweating syndrome 1 | 272430 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR010457 | Immunoglobulin C2-set-like, ligand-binding |
| Domain | IPR015152 | Growth hormone/erythropoietin receptor, ligand binding |
| Family | IPR050379 | Type I Cytokine Receptor |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Fibronectin type III | Fibronectin type III superfamily | Growth hormone/erythropoietin receptor, ligand binding | Immunoglobulin C2-set-like, ligand-binding | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Type I Cytokine Receptor |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6DG28 | InterPro | 389 | |||||||
| UniProtKB:A0A8M3B7V3 | InterPro | 388 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
crlf1a-201
(1)
|
Ensembl | 2,496 nt | ||
| ncRNA |
crlf1a-002
(1)
|
Ensembl | 792 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers