ift74

ID

ZDB-GENE-040718-81

Name

intraflagellar transport 74

Symbol

ift74 Nomenclature History

Previous Names

zgc:92052

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable beta-tubulin binding activity. Predicted to be involved in intraciliary transport involved in cilium assembly. Predicted to be part of intraciliary transport particle B. Predicted to be active in cilium. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 22; Joubert syndrome; and spermatogenic failure 58. Orthologous to human IFT74 (intraflagellar transport 74).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Zhu et al., 2021

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 11 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ift74 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Bardet-Biedl syndrome 22	Alliance	Bardet-Biedl syndrome 22	617119
spermatogenic failure 58	Alliance	Spermatogenic failure 58	619585
		Joubert syndrome 40	619582

Associated With ift74 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR029602	Intraflagellar transport protein 74

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M9PXA7	InterPro	583
UniProtKB:Q6DHU7	InterPro	486
UniProtKB:A0A8M9Q8D0	InterPro	603
UniProtKB:A0AC58JIA8	InterPro	603
UniProtKB:A0AC58JIB5	InterPro	583
UniProtKB:A0AC58JIC0	InterPro	583
UniProtKB:A0AC58JIC1	InterPro	583