Gene
lbx1a
- ID
- ZDB-GENE-040724-40
- Name
- ladybird homeobox 1a
- Symbol
- lbx1a Nomenclature History
- Previous Names
-
- lbx1b (1)
- si:busm1-265n4.1
- si:ch211-103o12.1
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including anterior migratory muscle precursor stream; hindbrain neural plate; muscle; nervous system; and pectoral fin. Human ortholog(s) of this gene implicated in congenital central hypoventilation syndrome. Orthologous to human LBX1 (ladybird homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Juárez-Morales et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?Central hypoventilation syndrome, congenital, 3 | 619483 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Helix-turn-helix motif | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | LBX Family Transcription Factors |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q6ZM39 | InterPro | 269 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
lbx1a-201
(1)
|
Ensembl | 1,459 nt | ||
| mRNA | ottdart00000002272 (1) | Havana | 810 nt |
Interactions and Pathways
No data available
Plasmids
No data available