ZFIN is now using GRCz12tu for Genomic Data
Gene
nrros
- ID
- ZDB-GENE-040808-36
- Name
- negative regulator of reactive oxygen species
- Symbol
- nrros Nomenclature History
- Previous Names
-
- lrrc33
- zgc:100989
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable receptor ligand inhibitor activity and signaling receptor activity. Predicted to be involved in several processes, including inflammatory response; microglia development; and positive regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in cell surface and endoplasmic reticulum. Predicted to be active in plasma membrane. Is expressed in hematopoietic cell; intermediate cell mass of mesoderm; vein; and ventral mesoderm. Orthologous to human NRROS (negative regulator of reactive oxygen species).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7148958 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Seizures, early-onset, with neurodegeneration and brain calcification | 618875 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | BspA-type LRR region | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype | Multifunctional Developmental and Immune Receptor |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q6AXL3 | InterPro | 685 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers