sel1l

ID

ZDB-GENE-041001-122

Name

SEL1L adaptor subunit of SYVN1 ubiquitin ligase

Symbol

sel1l Nomenclature History

Previous Names

fj60e07
si:dkey-177p2.3 (1)
wu:fj60e07

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to be involved in ERAD pathway. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including digestive system; eye; hatching gland; pleuroperitoneal region; and polster. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human SEL1L (SEL1L adaptor subunit of SYVN1 ubiquitin ligase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu1578 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Barbieri et al., 2017
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sel1l Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Neurodevelopmental disorder with hypotonia, poor growth, dysmorphic facies, and agammaglobulinemia	621068
		?Neurodevelopmental disorder with poor growth, absent speech, progressive ataxia, and dysmorphic facies	621067

Associated With sel1l Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000562	Fibronectin type II domain
Family	IPR050767	Sel1/AlgK
Homologous_superfamily	IPR011990	Tetratricopeptide-like helical domain superfamily
Homologous_superfamily	IPR013806	Kringle-like fold
Homologous_superfamily	IPR036943	Fibronectin type II domain superfamily
Repeat	IPR006597	Sel1-like repeat