usp4

ID

ZDB-GENE-041008-187

Name

ubiquitin specific peptidase 4 (proto-oncogene)

Symbol

usp4 Nomenclature History

Previous Names

im:7139722
unpEL (1)
wu:fa11d11

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable cysteine-type deubiquitinase activity. Acts upstream of or within convergent extension; negative regulation of toll-like receptor signaling pathway; and protein deubiquitination. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human USP4 (ubiquitin specific peptidase 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7139722 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With usp4 Human Ortholog

No data available

Associated With usp4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018200	Ubiquitin specific protease, conserved site
Domain	IPR001394	Peptidase C19, ubiquitin carboxyl-terminal hydrolase
Domain	IPR006615	Peptidase C19, ubiquitin-specific peptidase, DUSP domain
Domain	IPR028135	Ubiquitin-like domain, USP-type
Domain	IPR029346	Ubiquitin carboxyl-terminal hydrolase, C-terminal
Family	IPR050185	Ubiquitin carboxyl-terminal hydrolase
Homologous_superfamily	IPR035927	DUSP-like superfamily
Homologous_superfamily	IPR038765	Papain-like cysteine peptidase superfamily