ZFIN is now using GRCz12tu for Genomic Data
Gene

ank2b

ID
ZDB-GENE-041010-165
Name
ankyrin 2b, neuronal
Symbol
ank2b Nomenclature History
Previous Names
  • ank2
  • zgc:101738 (1)
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Genome Assembly
GRCz12tu
Annotation Status
Current
Description
Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in protein localization to plasma membrane. Predicted to act upstream of or within proteolysis and signal transduction. Predicted to be located in several cellular components, including T-tubule; lysosome; and postsynaptic membrane. Is expressed in central nervous system; cranial ganglion; optic vesicle; and retinal ganglion cell layer. Human ortholog(s) of this gene implicated in ankyrin-B-related cardiac arrhythmia; atrial fibrillation; long QT syndrome; and sick sinus syndrome. Orthologous to human ANK2 (ankyrin 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ank2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
ankyrin-B-related cardiac arrhythmia Alliance Cardiac arrhythmia, ankyrin-B-related 600919
ankyrin-B-related cardiac arrhythmia Alliance Long QT syndrome 4 600919
Associated With ank2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR001969 Aspartic peptidase, active site
Domain IPR000488 Death domain
Domain IPR000906 ZU5 domain
Domain IPR040745 Ankyrin, UPA domain
Family IPR051165 Multifunctional Ankyrin Repeat Domain-Containing Protein
Homologous_superfamily IPR011029 Death-like domain superfamily
Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
Repeat IPR002110 Ankyrin repeat
Domain Details Per Protein
Protein Additional Resources Length Ankyrin repeat Ankyrin repeat-containing domain superfamily Ankyrin, UPA domain Aspartic peptidase, active site Death domain Death-like domain superfamily Multifunctional Ankyrin Repeat Domain-Containing Protein ZU5 domain
UniProtKB:A0A8M9Q7R7 InterPro 3532
UniProtKB:A0A8M9Q1F0 InterPro 3626
UniProtKB:A0A8M9QBV6 InterPro 3608
UniProtKB:A0A8M9PNT0 InterPro 3622
UniProtKB:A0A8M9Q7R2 InterPro 3603
UniProtKB:A0A8M9PNV7 InterPro 1513
UniProtKB:A0A8M9QBY0 InterPro 2668
UniProtKB:A0A8M9Q7T1 InterPro 1991
UniProtKB:A0A8M9QGV2 InterPro 3608
UniProtKB:A0A8M9Q1I9 InterPro 2002
UniProtKB:A0A8M9PNS3 InterPro 3630
UniProtKB:A0A8M9QGU1 InterPro 3631
UniProtKB:A0A8M1PAL4 InterPro 1754
UniProtKB:A0A8M9QGV9 InterPro 3601
UniProtKB:A0A8M9QGW4 InterPro 3508
UniProtKB:A0A8M9Q7S2 InterPro 3308
UniProtKB:A0A8M9Q1H0 InterPro 3563
UniProtKB:A0A8M9PNT8 InterPro 3589
UniProtKB:A0A8M9QBW8 InterPro 3502
UniProtKB:A0A8M9PNT4 InterPro 3604
UniProtKB:A0A8M9Q1F7 InterPro 3620
UniProtKB:A0A8M9QBW2 InterPro 3596
UniProtKB:A0A8M9Q7S6 InterPro 2679
UniProtKB:A0A8M9PNU3 InterPro 3483
UniProtKB:A0A8M9QBY5 InterPro 1524
UniProtKB:A0A8M9QGX0 InterPro 3276
UniProtKB:A0A8M9Q1G4 InterPro 3604
UniProtKB:A0A8M9QGX6 InterPro 2669
UniProtKB:A0A8M9Q1H7 InterPro 3482
UniProtKB:A0A8M9PNV1 InterPro 2598
UniProtKB:A0A8M9QBV0 InterPro 3622
UniProtKB:A0A8M9QBX3 InterPro 3275
UniProtKB:A0A8M9Q7Q0 InterPro 3633
UniProtKB:A0A8M9Q1I2 InterPro 2680
UniProtKB:A0A8M9Q1E3 InterPro 3634
UniProtKB:A0A8M9QGU6 InterPro 3623
UniProtKB:A0A8M9Q7Q4 InterPro 3623
UniProtKB:A0A8M9Q7Q9 InterPro 3616
UniProtKB:A0A8M9PNU7 InterPro 2805
UniProtKB:A0A8M9QGY1 InterPro 1882
UniProtKB:A0AB13AA63 InterPro 3470
UniProtKB:A0AB32TRB0 InterPro 3643
UniProtKB:A0AB32TRD3 InterPro 3597
UniProtKB:A0AB32TRE9 InterPro 3598
UniProtKB:A0AB32TRF1 InterPro 2814
UniProtKB:A0AB32TRG4 InterPro 3284
UniProtKB:A0AB32TSA0 InterPro 3632
UniProtKB:A0AB32TSB3 InterPro 3542
UniProtKB:A0AB32TSD0 InterPro 2677
UniProtKB:A0AB32TSL4 InterPro 3635
UniProtKB:A0AB32TSN4 InterPro 3555
UniProtKB:A0AB32TSQ0 InterPro 2678
UniProtKB:A0AB32TTW6 InterPro 3629
UniProtKB:A0AB32TTW7 InterPro 3631
UniProtKB:A0AB32TTY2 InterPro 3541
UniProtKB:A0AB32TTY4 InterPro 3522
UniProtKB:A0AB32TTZ8 InterPro 2011
UniProtKB:A0AB32TUN8 InterPro 3639
UniProtKB:A0AB32TUQ8 InterPro 3588
UniProtKB:A0AB32TUS6 InterPro 2689
UniProtKB:A0AB32TUU9 InterPro 3625
UniProtKB:A0AB32TUW7 InterPro 3517
UniProtKB:A0AB32TWK6 InterPro 3635
UniProtKB:A0AB32TWK7 InterPro 3617
UniProtKB:A0AB32TWM2 InterPro 3572
UniProtKB:A0AB32TWM3 InterPro 3511
UniProtKB:A0AB32TWP2 InterPro 2688
UniProtKB:A0AB32TX59 InterPro 3612
UniProtKB:A0AB32TX74 InterPro 3317
UniProtKB:A0AB32TY78 InterPro 3610
UniProtKB:A0AB32TY94 InterPro 3285
UniProtKB:A0AB32TY98 InterPro 3630
UniProtKB:A0AB32TYB5 InterPro 3530
UniProtKB:A0AB32TYC9 InterPro 2000
UniProtKB:A0AB32TYD7 InterPro 3613
UniProtKB:A0AB32TYF6 InterPro 3492
UniProtKB:A0AB32TZH7 InterPro 3612
UniProtKB:A0AB32TZJ5 InterPro 3491
UniProtKB:A0AC58FYD6 InterPro 3616
UniProtKB:A0AC58FYD7 InterPro 3626
UniProtKB:A0AC58FYD8 InterPro 3609
UniProtKB:A0AC58FYE2 InterPro 3615
UniProtKB:A0AC58FYE3 InterPro 3614
UniProtKB:A0AC58FYE4 InterPro 3617
UniProtKB:A0AC58FYE9 InterPro 3608
UniProtKB:A0AC58FYF1 InterPro 3599
UniProtKB:A0AC58FYF3 InterPro 3594
UniProtKB:A0AC58FYF4 InterPro 2332
UniProtKB:A0AC58FYF5 InterPro 2340
UniProtKB:A0AC58FYF6 InterPro 3623
UniProtKB:A0AC58FYF7 InterPro 3596
UniProtKB:A0AC58FYF9 InterPro 2459
UniProtKB:A0AC58FYG1 InterPro 2333
UniProtKB:A0AC58FYG2 InterPro 2433
UniProtKB:A0AC58FYG5 InterPro 2319
UniProtKB:A0AC58FYG6 InterPro 1799
UniProtKB:A0AC58FYH0 InterPro 1792
UniProtKB:A0AC58FYH2 InterPro 3592
UniProtKB:A0AC58FYH3 InterPro 1778
UniProtKB:A0AC58FYH5 InterPro 1755
UniProtKB:A0AC58FYH7 InterPro 1781
UniProtKB:A0AC58FYI1 InterPro 1892
UniProtKB:A0AC58FYI3 InterPro 1777
UniProtKB:A0AC58FYI5 InterPro 1780
UniProtKB:A0AC58FYI9 InterPro 1791
UniProtKB:A0AC58FYJ6 InterPro 1766
UniProtKB:A0AC58FYS6 InterPro 3619
UniProtKB:A0AC58FYV1 InterPro 2467
UniProtKB:A0AC58FYV3 InterPro 3622
UniProtKB:A0AC58FYW8 InterPro 1788
UniProtKB:A0AC58FYX3 InterPro 3597
UniProtKB:A0AC58FYX4 InterPro 3604
UniProtKB:A0AC58FYX5 InterPro 3591
UniProtKB:A0AC58FYY9 InterPro 1909
UniProtKB:A0AC58FYZ0 InterPro 1789
UniProtKB:A0AC58FYZ1 InterPro 3600
UniProtKB:A0AC58FYZ9 InterPro 1767
UniProtKB:A0AC58FZ02 InterPro 1766
UniProtKB:A0AC58FZ07 InterPro 1890
UniProtKB:A0AC58FZ19 InterPro 1765
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA ank2b-201 (1)
Ensembl
Ensembl 1,495 nt
ZFIN BLAST
mRNA ank2b-202 (1)
Ensembl
Ensembl 294 nt
ZFIN BLAST
mRNA ank2b-203 (1)
Ensembl
Ensembl 713 nt
ZFIN BLAST
mRNA ank2b-204 (1)
Ensembl
Ensembl 1,401 nt
ZFIN BLAST
mRNA ank2b-205 (1)
Ensembl
Ensembl 11,061 nt
ZFIN BLAST
mRNA ank2b-206 (1)
Ensembl
Ensembl 6,814 nt
ZFIN BLAST
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Genome Browsers
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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