ZFIN is now using GRCz12tu for Genomic Data
Gene
myo5aa
- ID
- ZDB-GENE-041027-2
- Name
- myosin VAa
- Symbol
- myo5aa Nomenclature History
- Previous Names
-
- myo5a
- si:dkey-266j9.1
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actin filament organization and endocytosis. Predicted to be active in actin cytoskeleton; cytoplasm; and membrane. Is expressed in central nervous system; dorsolateral placode; intestine; neural tube; and neuron neural crest derived. Human ortholog(s) of this gene implicated in Griscelli syndrome type 1. Orthologous to human MYO5A (myosin VA).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Griscelli syndrome type 1 | Alliance | Griscelli syndrome, type 1 | 214450 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR000048 | IQ motif, EF-hand binding site |
| Domain | IPR001609 | Myosin head, motor domain-like |
| Domain | IPR002710 | Dilute domain |
| Domain | IPR004009 | Myosin, SH3 domain |
| Domain | IPR036103 | Class V myosin, motor domain |
| Domain | IPR037988 | Myosin 5a, cargo-binding domain |
| Domain | IPR058662 | Unconventional myosin-Va/b domain |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
myo5aa-201
(1)
|
Ensembl | 5,535 nt | ||
| mRNA |
myo5aa-202
(1)
|
Ensembl | 5,535 nt | ||
| mRNA |
myo5aa-203
(1)
|
Ensembl | 844 nt | ||
| mRNA |
myo5aa-204
(1)
|
Ensembl | 5,735 nt | ||
| mRNA |
myo5aa-206
(1)
|
Ensembl | 5,809 nt | ||
| ncRNA |
myo5aa-005
(1)
|
Ensembl | 815 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers