ZFIN is now using GRCz12tu for Genomic Data

Gene

lepb

ID

ZDB-GENE-041210-183

Name

leptin b

Symbol

lepb Nomenclature History

Previous Names

si:dkey-21o22.1

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable hormone activity. Acts upstream of or within glucose homeostasis; regulation of primary metabolic process; and response to starvation. Predicted to be located in extracellular region. Is expressed in several structures, including digestive system; gill; heart; hypophysis; and pleuroperitoneal region. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; congenital leptin deficiency; liver disease (multiple); lung disease (multiple); and type 2 diabetes mellitus. Orthologous to human LEP (leptin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

18 figures from 17 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 12 figures from 6 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lepb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital leptin deficiency	Alliance	Obesity, morbid, due to leptin deficiency	614962

Associated With lepb Via Experimental Models

Human Disease	Fish	Conditions	Citations
type 2 diabetes mellitus	lepb^ibl54/ibl54 (AB/TL)	standard conditions	He et al., 2021
type 2 diabetes mellitus	lepb^ibl55/ibl55 (AB/TL)	standard conditions	He et al., 2021

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR000065	Leptin
Homologous_superfamily	IPR009079	Four-helical cytokine-like, core

Domain Details Per Protein

Protein	Additional Resources	Length	Four-helical cytokine-like, core	Leptin
UniProtKB:C4WYH6	InterPro	168

Transcripts

Genome Browsers

NCBI Map Viewer

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	lepb-201 (1) Ensembl	Ensembl		589 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI Map Viewer

ZFIN

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations