ZFIN is now using GRCz12tu for Genomic Data
Gene
lamb1b
- ID
- ZDB-GENE-041210-197
- Name
- laminin, beta 1b
- Symbol
- lamb1b Nomenclature History
- Previous Names
-
- si:dkey-183c16.5
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable integrin binding activity. Predicted to be involved in several processes, including axon guidance; basement membrane assembly; and substrate adhesion-dependent cell spreading. Predicted to be located in basement membrane. Predicted to be part of laminin trimer. Is expressed in several structures, including fin; heart; median fin fold; nervous system; and notochord. Human ortholog(s) of this gene implicated in autistic disorder and leukoencephalopathy with variable cortical brain malformations and/or hydrocephalus. Orthologous to human LAMB1 (laminin subunit beta 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| leukoencephalopathy with variable cortical brain malformations and/or hydrocephalus | Alliance | Leukoencephalopathy with variable cortical brain malformations and/or hydrocephalus | 615191 |
| Leukoencephalopathy without lacunae, adult-onset | 621424 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR002049 | Laminin-type EGF domain |
| Domain | IPR008211 | Laminin, N-terminal |
| Domain | IPR013015 | Laminin IV type B |
| Domain | IPR056558 | LAMB1/2/3/4, helical domain |
| Domain | IPR056863 | Laminin/attractin/netrin-like, EGF domain |
| Family | IPR050440 | Laminin/Netrin Extracellular Matrix |
Domain Details Per Protein
| Protein | Additional Resources | Length | EGF-like domain | LAMB1/2/3/4, helical domain | Laminin/attractin/netrin-like, EGF domain | Laminin IV type B | Laminin/Netrin Extracellular Matrix | Laminin, N-terminal | Laminin-type EGF domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1REL9 | InterPro | 1767 | |||||||
| UniProtKB:A0AC58J6V6 | InterPro | 1534 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
lamb1b-201
(1)
|
Ensembl | 5,573 nt | ||
| mRNA |
lamb1b-202
(1)
|
Ensembl | 5,311 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers