ZFIN is now using GRCz12tu for Genomic Data
Gene
ppm1kb
- ID
- ZDB-GENE-050306-8
- Name
- protein phosphatase, Mg2+/Mn2+ dependent 1Kb
- Symbol
- ppm1kb Nomenclature History
- Previous Names
-
- pp2cm (1)
- ppm1k
- im:6912645
- zgc:113207
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable protein serine/threonine phosphatase activity. Acts upstream of or within several processes, including digestive tract development; liver development; and pancreas development. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in brain; heart; liver; neural tube; and trunk musculature. Human ortholog(s) of this gene implicated in maple syrup urine disease. Orthologous to human PPM1K (protein phosphatase, Mg2+/Mn2+ dependent 1K).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6912645 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Lu et al., 2007
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| mild variant of maple syrup urine disease | Alliance | Maple syrup urine disease, mild variant | 615135 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | PPM-type phosphatase, divalent cation binding | PPM-type phosphatase-like domain | PPM-type phosphatase-like domain superfamily | Protein phosphatase 2C |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B6X8 | InterPro | 242 | ||||
| UniProtKB:F6PA41 | InterPro | 188 | ||||
| UniProtKB:A0A8M1P874 | InterPro | 372 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers