xpo1a

ID

ZDB-GENE-050309-201

Name

exportin 1 (CRM1 homolog, yeast) a

Symbol

xpo1a Nomenclature History

Previous Names

fb93b03
im:7151655
wu:fb93b03

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable nuclear export signal receptor activity. Acts upstream of or within brain development. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colorectal cancer; gastric adenocarcinoma; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to human XPO1 (exportin 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7151655 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Bagheri et al., 2016
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With xpo1a Human Ortholog

No data available

Associated With xpo1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001494	Importin-beta, N-terminal domain
Domain	IPR013598	Exportin-1/Importin-beta-like
Domain	IPR014877	Exportin-1, C-terminal
Family	IPR045065	Exportin-1/5
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR016024	Armadillo-type fold
Repeat	IPR040485	Exportin-1, repeat 3
Repeat	IPR041123	Chromosome region maintenance repeat
Repeat	IPR041235	Exportin-1, repeat 2