ZFIN is now using GRCz12tu for Genomic Data
Gene
pik3r4
- ID
- ZDB-GENE-050309-84
- Name
- phosphoinositide-3-kinase, regulatory subunit 4
- Symbol
- pik3r4 Nomenclature History
- Previous Names
-
- im:7148788
- vps15 (1)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in late endosome to vacuole transport; pexophagy; and protein targeting to vacuole. Predicted to act upstream of or within macroautophagy and protein phosphorylation. Predicted to be located in autophagosome and endosome. Predicted to be part of phosphatidylinositol 3-kinase complex, class III, type I and phosphatidylinositol 3-kinase complex, class III, type II. Predicted to be active in late endosome and nucleus-vacuole junction. Is expressed in head; pronephric duct; and skeletal muscle. Orthologous to human PIK3R4 (phosphoinositide-3-kinase regulatory subunit 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7148788 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Stoetzel et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR055231 | VPS15-like, helical domain |
| Family | IPR045162 | Serine/threonine-protein kinase Vps15-like |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011989 | Armadillo-like helical |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
| Repeat | IPR021133 | HEAT, type 2 |
Domain Details Per Protein
| Protein | Additional Resources | Length | Armadillo-like helical | Armadillo-type fold | HEAT, type 2 | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Serine/threonine-protein kinase Vps15-like | VPS15-like, helical domain | WD40 repeat | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PN73 | InterPro | 1347 | |||||||||||
| UniProtKB:E9QFS6 | InterPro | 1340 | |||||||||||
| UniProtKB:A0A8M1QHR9 | InterPro | 1384 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pik3r4-201
(1)
|
Ensembl | 4,086 nt | ||
| mRNA |
pik3r4-202
(1)
|
Ensembl | 4,641 nt | ||
| mRNA |
pik3r4-203
(1)
|
Ensembl | 4,065 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers