kcnab1a

ID

ZDB-GENE-050327-79

Name

potassium voltage-gated channel subfamily A regulatory beta subunit 1a

Symbol

kcnab1a Nomenclature History

Previous Names

kcnab1
zgc:113627 (1)

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable alcohol dehydrogenase (NADP+) activity; potassium channel regulator activity; and transmembrane transporter binding activity. Predicted to be involved in regulation of potassium ion transmembrane transport. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in juxtaparanode region of axon. Is expressed in several structures, including heart; immature eye; myotome; nervous system; and pharyngeal arch. Human ortholog(s) of this gene implicated in temporal lobe epilepsy. Orthologous to human KCNAB1 (potassium voltage-gated channel subfamily A regulatory beta subunit 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7159135 (15 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kcnab1a Human Ortholog

No data available

Associated With kcnab1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR023210	NADP-dependent oxidoreductase domain
Family	IPR005399	Potassium channel, voltage-dependent, beta subunit, KCNAB-related
Family	IPR005400	Potassium channel, voltage-dependent, beta subunit, KCNAB1
Family	IPR005983	Potassium channel, voltage-dependent, beta subunit, KCNAB
Homologous_superfamily	IPR036812	NAD(P)-dependent oxidoreductase domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:Q58EC4	InterPro	398
UniProtKB:A0A8M9PQ73	InterPro	403
UniProtKB:A0A8M9PM35	InterPro	423
UniProtKB:A0A8M9PFF1	InterPro	406
UniProtKB:A0A8M9P126	InterPro	418
UniProtKB:A0A8M9PA23	InterPro	411
UniProtKB:A0AB32TDC2	InterPro	350
UniProtKB:A0AC58HT57	InterPro	345
UniProtKB:A0AC58HT58	InterPro	295
UniProtKB:A0AC58HT59	InterPro	418
UniProtKB:A0AC58HT61	InterPro	423
UniProtKB:A0AC58HT62	InterPro	355
UniProtKB:A0AC58HT64	InterPro	403
UniProtKB:A0AC58HT66	InterPro	295
UniProtKB:A0AC58HT83	InterPro	350
UniProtKB:A0AC58HT84	InterPro	418
UniProtKB:A0AC58HT86	InterPro	406
UniProtKB:A0AC58HTA1	InterPro	411