Gene
srd5a2b
- ID
- ZDB-GENE-050417-182
- Name
- steroid-5-alpha-reductase, alpha polypeptide 2b
- Symbol
- srd5a2b Nomenclature History
- Previous Names
-
- zgc:112455
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable 3-oxo-5-alpha-steroid 4-dehydrogenase activity. Predicted to be involved in androgen biosynthetic process and male gonad development. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in neuronal cell body. Is expressed in hindbrain; pectoral fin; and testis. Human ortholog(s) of this gene implicated in hypospadias and prostate cancer. Orthologous to human SRD5A2 (steroid 5 alpha-reductase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:112455 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Pseudovaginal perineoscrotal hypospadias | 264600 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | 3-oxo-5-alpha-steroid 4-dehydrogenase | 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal | 3-oxo-5-alpha-steroid 4-dehydrogenase/very-long-chain enoyl-CoA reductase |
|---|---|---|---|---|---|
| UniProtKB:A0A8M2B3D1 | InterPro | 252 | |||
| UniProtKB:Q566V2 | InterPro | 217 | |||
| UniProtKB:A0AB13AAN1 | InterPro | 252 | |||
| UniProtKB:A0A8M1N5I5 | InterPro | 231 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
srd5a2b-201
(1)
|
Ensembl | 1,277 nt |
Interactions and Pathways
No data available
Plasmids
No data available