Gene
apoa4a
- ID
- ZDB-GENE-050417-469
- Name
- apolipoprotein A-IV a
- Symbol
- apoa4a Nomenclature History
- Previous Names
-
- zgc:112992
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable cholesterol transfer activity; phosphatidylcholine-sterol O-acyltransferase activator activity; and phospholipid binding activity. Predicted to be involved in several processes, including acylglycerol homeostasis; cholesterol efflux; and phospholipid efflux. Predicted to act upstream of or within lipid transport. Predicted to be located in extracellular region. Predicted to be part of several cellular components, including chylomicron; low-density lipoprotein particle; and very-low-density lipoprotein particle. Predicted to be active in extracellular vesicle. Is expressed in gut; intestine; liver; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant tubulointerstitial kidney disease 6; colitis (multiple); coronary artery disease (multiple); familial hyperlipidemia (multiple); and type 2 diabetes mellitus. Orthologous to several human genes including APOA4 (apolipoprotein A4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7160072 (3 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant tubulointerstitial kidney disease 6 | Alliance | Tubulointerstitial kidney disease, autosomal dominant 6 | 621106 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Apolipoprotein A1/A4/E | Apolipoprotein A/E |
|---|---|---|---|---|
| UniProtKB:Q566Q0 | InterPro | 234 | ||
| UniProtKB:A0A8M9P1T6 | InterPro | 252 | ||
| UniProtKB:A0A8M1N5N8 | InterPro | 252 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
apoa4a-201
(1)
|
Ensembl | 1,042 nt | ||
| mRNA |
apoa4a-202
(1)
|
Ensembl | 894 nt | ||
| mRNA |
apoa4a-203
(1)
|
Ensembl | 708 nt |
Interactions and Pathways
No data available
Plasmids