ZFIN is now using GRCz12tu for Genomic Data
Gene
gsr
- ID
- ZDB-GENE-050522-116
- Name
- glutathione reductase
- Symbol
- gsr Nomenclature History
- Previous Names
-
- zgc:110010 (1)
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable flavin adenine dinucleotide binding activity and glutathione-disulfide reductase (NADPH) activity. Predicted to be involved in cell redox homeostasis; cellular response to oxidative stress; and glutathione metabolic process. Predicted to be active in cytosol and mitochondrion. Is expressed in intestinal bulb; liver; and macrophage. Human ortholog(s) of this gene implicated in congenital nonspherocytic hemolytic anemia 10 and macular degeneration. Orthologous to human GSR (glutathione-disulfide reductase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110010 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital nonspherocytic hemolytic anemia 10 | Alliance | Anemia, congenital, nonspherocytic hemolytic, 10, glutathione reductase deficient | 618660 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR012999 | Pyridine nucleotide-disulphide oxidoreductase, class I, active site |
| Domain | IPR004099 | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain |
| Domain | IPR023753 | FAD/NAD(P)-binding domain |
| Family | IPR001100 | Pyridine nucleotide-disulphide oxidoreductase, class I |
| Family | IPR006322 | Glutathione reductase, eukaryote/bacterial |
| Family | IPR046952 | Glutathione reductase/thioredoxin reductase-like |
| Homologous_superfamily | IPR016156 | FAD/NAD-linked reductase, dimerisation domain superfamily |
| Homologous_superfamily | IPR036188 | FAD/NAD(P)-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | FAD/NAD-linked reductase, dimerisation domain superfamily | FAD/NAD(P)-binding domain | FAD/NAD(P)-binding domain superfamily | Glutathione reductase, eukaryote/bacterial | Glutathione reductase/thioredoxin reductase-like | Pyridine nucleotide-disulphide oxidoreductase, class I | Pyridine nucleotide-disulphide oxidoreductase, class I, active site | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q503Y5 | InterPro | 425 | ||||||||
| UniProtKB:A0A8M6Z2M1 | InterPro | 500 | ||||||||
| UniProtKB:A0A8M9QB21 | InterPro | 469 | ||||||||
| UniProtKB:A0A8M2BHF6 | InterPro | 500 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
gsr-205
(1)
|
Ensembl | 870 nt | ||
| mRNA |
gsr-201
(1)
|
Ensembl | 1,976 nt | ||
| mRNA |
gsr-202
(1)
|
Ensembl | 1,545 nt | ||
| mRNA |
gsr-206
(1)
|
Ensembl | 1,318 nt | ||
| mRNA |
gsr-207
(1)
|
Ensembl | 895 nt | ||
| mRNA |
gsr-208
(1)
|
Ensembl | 660 nt | ||
| mRNA |
gsr-209
(1)
|
Ensembl | 1,290 nt | ||
| ncRNA |
gsr-003
(1)
|
Ensembl | 814 nt | ||
| ncRNA |
gsr-004
(1)
|
Ensembl | 567 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers