Gene
hs6st1a
- ID
- ZDB-GENE-050524-1
- Name
- heparan sulfate 6-O-sulfotransferase 1a
- Symbol
- hs6st1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Enables heparan sulfate 6-O-sulfotransferase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process, enzymatic modification. Predicted to be located in membrane. Is expressed in several structures, including immature eye; nervous system; neural keel; neural tube; and polster. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 15 with or without anosmia. Orthologous to human HS6ST1 (heparan sulfate 6-O-sulfotransferase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110038 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypogonadotropic hypogonadism 15 with or without anosmia | Alliance | {Hypogonadotropic hypogonadism 15 with or without anosmia} | 614880 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR001969 | Aspartic peptidase, active site |
| Domain | IPR000477 | Reverse transcriptase domain |
| Domain | IPR001584 | Integrase, catalytic core |
| Domain | IPR003309 | SCAN domain |
| Domain | IPR018061 | Retropepsins |
| Domain | IPR041373 | Reverse transcriptase, RNase H-like domain |
| Domain | IPR041588 | Integrase zinc-binding domain |
| Domain | IPR054465 | Integrase p58-like, C-terminal domain |
| Family | IPR005331 | Sulfotransferase |
| Family | IPR010635 | Heparan sulphate 6-sulfotransferase/Protein-tyrosine sulfotransferase |
| Family | IPR050951 | Retrovirus-related Pol polyprotein |
| Homologous_superfamily | IPR012337 | Ribonuclease H-like superfamily |
| Homologous_superfamily | IPR021109 | Aspartic peptidase domain superfamily |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036397 | Ribonuclease H superfamily |
| Homologous_superfamily | IPR038269 | SCAN domain superfamily |
| Homologous_superfamily | IPR043128 | Reverse transcriptase/Diguanylate cyclase domain |
| Homologous_superfamily | IPR043502 | DNA/RNA polymerase superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Aspartic peptidase, active site | Aspartic peptidase domain superfamily | DNA/RNA polymerase superfamily | Heparan sulphate 6-sulfotransferase/Protein-tyrosine sulfotransferase | Integrase, catalytic core | Integrase p58-like, C-terminal domain | Integrase zinc-binding domain | P-loop containing nucleoside triphosphate hydrolase | Retropepsins | Retrovirus-related Pol polyprotein | Reverse transcriptase/Diguanylate cyclase domain | Reverse transcriptase domain | Reverse transcriptase, RNase H-like domain | Ribonuclease H-like superfamily | Ribonuclease H superfamily | SCAN domain | SCAN domain superfamily | Sulfotransferase |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q56UJ5 | InterPro | 413 | ||||||||||||||||||
| UniProtKB:A0AB13ABZ8 | InterPro | 413 | ||||||||||||||||||
| UniProtKB:A0AB32TZX1 | InterPro | 1354 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hs6st1a-201
(1)
|
Ensembl | 737 nt | ||
| mRNA |
hs6st1a-202
(1)
|
Ensembl | 1,242 nt |
Interactions and Pathways
No data available
Plasmids
No data available