ZFIN is now using GRCz12tu for Genomic Data
Gene
dnm2a
- ID
- ZDB-GENE-050913-84
- Name
- dynamin 2a
- Symbol
- dnm2a Nomenclature History
- Previous Names
-
- dnm2
- zgc:114072
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable GTPase activity and microtubule binding activity. Acts upstream of or within several processes, including chordate embryonic development; convergent extension; and somite development. Predicted to be located in several cellular components, including cytoplasmic vesicle; cytoskeleton; and uropod. Predicted to be active in several cellular components, including microtubule; plasma membrane; and synapse. Is expressed in several structures, including central nervous system; liver; otic vesicle; paraxial mesoderm; and pericardial region. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate B; centronuclear myopathy 1; and lethal congenital contracture syndrome. Orthologous to human DNM2 (dynamin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| centronuclear myopathy 1 | Alliance | Centronuclear myopathy 1 | 160150 |
| Charcot-Marie-Tooth disease dominant intermediate B | Alliance | Charcot-Marie-Tooth disease, axonal type 2M | 606482 |
| Charcot-Marie-Tooth disease dominant intermediate B | Alliance | Charcot-Marie-Tooth disease, dominant intermediate B | 606482 |
| lethal congenital contracture syndrome 5 | Alliance | Lethal congenital contracture syndrome 5 | 615368 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019762 | Dynamin, GTPase region, conserved site |
| Domain | IPR000375 | Dynamin stalk domain |
| Domain | IPR001401 | Dynamin, GTPase domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR003130 | Dynamin GTPase effector |
| Domain | IPR020850 | GTPase effector domain |
| Domain | IPR030381 | Dynamin-type guanine nucleotide-binding (G) domain |
| Domain | IPR045063 | Dynamin, N-terminal |
| Family | IPR022812 | Dynamin |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
- Genome Browsers