ZFIN is now using GRCz12tu for Genomic Data
Gene
il10
- ID
- ZDB-GENE-051111-1
- Name
- interleukin 10
- Symbol
- il10 Nomenclature History
- Previous Names
-
- zgc:194510
- zgc:194518
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable cytokine activity. Acts upstream of or within several processes, including negative regulation of inflammatory response; regulation of Notch signaling pathway; and response to bacterium. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in blood; digestive system; gill; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and liver disease (multiple). Orthologous to human IL10 (interleukin 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 82 figures from 65 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| graft-versus-host disease | Alliance | {Graft-versus-host disease, protection against} | 614395 |
| rheumatoid arthritis | Alliance | {Rheumatoid arthritis, progression of} | 180300 |
| {HIV-1, susceptibility to} | 609423 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Four-helical cytokine-like, core | Interleukin-10 | Interleukin-10/19/20/24/26 |
|---|---|---|---|---|---|
| UniProtKB:Q5EFQ8 | InterPro | 180 | |||
| UniProtKB:A0AC58GQH4 | InterPro | 195 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers