kcnj11

ID

ZDB-GENE-060308-2

Name

potassium inwardly rectifying channel subfamily J member 11

Symbol

kcnj11 Nomenclature History

Previous Names

Kir6.2 (1)

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable ATP-activated inward rectifier potassium channel activity. Predicted to contribute to inward rectifier potassium channel activity. Acts upstream of or within type B pancreatic cell development. Predicted to be located in membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Is expressed in several structures, including dermomyotome; endocrine system; heart; pectoral fin; and pharyngeal arch. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple). Orthologous to human KCNJ11 (potassium inwardly rectifying channel subfamily J member 11).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from O'Hare et al., 2016
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kcnj11 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
familial hyperinsulinemic hypoglycemia 2	Alliance	Hyperinsulinemic hypoglycemia, familial, 2	601820
maturity-onset diabetes of the young type 13	Alliance	Maturity-onset diabetes of the young, type 13	616329
transient neonatal diabetes mellitus 3	Alliance	Diabetes mellitus, transient neonatal 3	610582
		Diabetes, permanent neonatal 2, with or without neurologic features	618856

Associated With kcnj11 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR040445	Potassium channel, inwardly rectifying, transmembrane domain
Domain	IPR041647	Inward rectifier potassium channel, C-terminal
Family	IPR003279	Potassium channel, inwardly rectifying, Kir6.2
Family	IPR016449	Potassium channel, inwardly rectifying, Kir
Homologous_superfamily	IPR013518	Potassium channel, inwardly rectifying, Kir, cytoplasmic
Homologous_superfamily	IPR014756	Immunoglobulin E-set