Gene
irf1a
- ID
- ZDB-GENE-060421-4031
- Name
- interferon regulatory factor 1a
- Symbol
- irf1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in immune system process and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including blood; digestive system; eye; immune system; and integument. Human ortholog(s) of this gene implicated in asthma; immunodeficiency 117; lung cancer (multiple); smallpox; and stomach cancer (multiple). Orthologous to human IRF1 (interferon regulatory factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 117 | Alliance | Immunodeficiency 117, mycobacteriosis, autosomal recessive | 620668 |
| lung cancer | Alliance | Nonsmall cell lung cancer, somatic | 211980 |
| stomach cancer | Alliance | Gastric cancer, somatic | 613659 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019817 | Interferon regulatory factor, conserved site |
| Domain | IPR001346 | Interferon regulatory factor, DNA-binding domain |
| Family | IPR017431 | Interferon regulatory factor-1/2 |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Interferon regulatory factor-1/2 | Interferon regulatory factor, conserved site | Interferon regulatory factor, DNA-binding domain | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AYR2 | InterPro | 250 | |||||
| UniProtKB:Q1RLP9 | InterPro PDB | 251 |
Interactions and Pathways
No data available
Plasmids
No data available