Gene
kmt2ba
- ID
- ZDB-GENE-060503-376
- Name
- lysine (K)-specific methyltransferase 2Ba
- Symbol
- kmt2ba Nomenclature History
- Previous Names
-
- mll4a
- si:rp71-15k1.2
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable histone H3K4 methyltransferase activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be part of histone methyltransferase complex. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 68; colorectal adenocarcinoma; dystonia 28, childhood-onset; and hepatocellular carcinoma. Orthologous to human KMT2B (lysine methyltransferase 2B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Sun et al., 2008
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant intellectual developmental disorder 68 | Alliance | Intellectual developmental disorder, autosomal dominant 68 | 619934 |
| dystonia 28, childhood-onset | Alliance | Dystonia 28, childhood-onset | 617284 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR003888 | FY-rich, N-terminal |
| Conserved_site | IPR003889 | FY-rich, C-terminal |
| Domain | IPR001214 | SET domain |
| Domain | IPR001965 | Zinc finger, PHD-type |
| Domain | IPR002857 | Zinc finger, CXXC-type |
| Domain | IPR003616 | Post-SET domain |
| Domain | IPR019787 | Zinc finger, PHD-finger |
| Domain | IPR034732 | Extended PHD (ePHD) domain |
| Domain | IPR047219 | Histone-lysine N-methyltransferase 2A/2B, SET domain |
| Homologous_superfamily | IPR011011 | Zinc finger, FYVE/PHD-type |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR036427 | Bromodomain-like superfamily |
| Homologous_superfamily | IPR046341 | SET domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Bromodomain-like superfamily | Extended PHD (ePHD) domain | FY-rich, C-terminal | FY-rich, N-terminal | Histone-lysine N-methyltransferase 2A/2B, SET domain | Post-SET domain | SET domain | SET domain superfamily | Zinc finger, CXXC-type | Zinc finger, FYVE/PHD-type | Zinc finger, PHD-finger | Zinc finger, PHD-type | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B683 | InterPro | 2862 | |||||||||||||
| UniProtKB:A0A8N7TDQ0 | InterPro | 2863 | |||||||||||||
| UniProtKB:A0A8M2B633 | InterPro | 2862 | |||||||||||||
| UniProtKB:A0AB32T9Q8 | InterPro | 2943 | |||||||||||||
| UniProtKB:A0AB32TDE4 | InterPro | 2944 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| antisense |
ottdart00000059906
(1)
|
Ensembl | 684 nt | ||
| mRNA |
kmt2ba-201
(1)
|
Ensembl | 9,950 nt | ||
| mRNA |
kmt2ba-202
(1)
|
Ensembl | 11,578 nt |
Interactions and Pathways
No data available
Plasmids
No data available