ZFIN is now using GRCz12tu for Genomic Data
Gene
slc9a3.1
- ID
- ZDB-GENE-060503-545
- Name
- solute carrier family 9 member A3, tandem duplicate 1
- Symbol
- slc9a3.1 Nomenclature History
- Previous Names
-
- nhe3a (1)
- si:dkey-3n22.4
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of intracellular pH; and sodium ion import across plasma membrane. Predicted to act upstream of or within proton transmembrane transport; regulation of pH; and sodium ion transport. Predicted to be located in apical plasma membrane; early endosome membrane; and recycling endosome membrane. Predicted to be active in brush border membrane. Is expressed in kidney. Human ortholog(s) of this gene implicated in congenital secretory sodium diarrhea 8; cystic fibrosis; exocrine pancreatic insufficiency; and gastrointestinal system disease. Orthologous to human SLC9A3 (solute carrier family 9 member A3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Yan et al., 2007
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital secretory sodium diarrhea 8 | Alliance | Diarrhea 8, secretory sodium, congenital | 616868 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cation/H+ exchanger, CPA1 family | Cation/H+ exchanger, transmembrane domain | Na+/H+ exchanger | Na+/H+ exchanger, isoforms 3/5 |
|---|---|---|---|---|---|---|
| UniProtKB:B7ZVJ6 | InterPro | 832 | ||||
| UniProtKB:A9XPA1 | InterPro | 832 | ||||
| UniProtKB:A0AB32T9J1 | InterPro | 831 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
slc9a3.1-201
(1)
|
Ensembl | 3,645 nt | ||
| mRNA |
slc9a3.1-202
(1)
|
Ensembl | 3,398 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers