Gene

rims2b

ID

ZDB-GENE-060503-893

Name

regulating synaptic membrane exocytosis 2b

Symbol

rims2b Nomenclature History

Previous Names

si:ch211-95i5.2

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to be a structural constituent of presynaptic active zone. Predicted to be involved in regulation of synaptic vesicle exocytosis; synaptic vesicle docking; and synaptic vesicle priming. Predicted to act upstream of or within exocytosis and intracellular protein transport. Predicted to be located in membrane and synapse. Predicted to be active in presynaptic active zone cytoplasmic component and presynaptic membrane. Orthologous to human RIMS2 (regulating synaptic membrane exocytosis 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rims2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Cone-rod synaptic disorder syndrome, congenital nonprogressive	618970

Associated With rims2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000008	C2 domain
Domain	IPR001478	PDZ domain
Domain	IPR010911	Rab-binding domain
Domain	IPR017455	Zinc finger, FYVE-related
Domain	IPR054386	RIM, zinc finger
Family	IPR039032	Rim-like
Homologous_superfamily	IPR011011	Zinc finger, FYVE/PHD-type
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR035892	C2 domain superfamily
Homologous_superfamily	IPR036034	PDZ superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	C2 domain	C2 domain superfamily	PDZ domain	PDZ superfamily	Rab-binding domain	Rim-like	RIM, zinc finger	Zinc finger, FYVE/PHD-type	Zinc finger, FYVE-related	Zinc finger, RING/FYVE/PHD-type
UniProtKB:A0A8M9PSB0	InterPro	1846

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	rims2b-201 (1) Ensembl	Ensembl	3,164 nt	Select Tool ZFIN BLAST
mRNA	rims2b-203 (1) Ensembl	Ensembl	679 nt	Select Tool ZFIN BLAST
mRNA	rims2b-204 (1) Ensembl	Ensembl	482 nt	Select Tool ZFIN BLAST
ncRNA	rims2b-005 (1) Ensembl	Ensembl	468 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations