ZFIN is now using GRCz12tu for Genomic Data

Gene

phldb1a

ID

ZDB-GENE-060526-272

Name

pleckstrin homology-like domain, family B, member 1a

Symbol

phldb1a Nomenclature History

Previous Names

phldb1
si:dkey-252h13.1

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to be involved in basement membrane organization. Predicted to be active in basal cortex. Human ortholog(s) of this gene implicated in osteogenesis imperfecta. Orthologous to human PHLDB1 (pleckstrin homology like domain family B member 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With phldb1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Osteogenesis imperfecta, type XXIII	620639

Associated With phldb1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000253	Forkhead-associated (FHA) domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR037810	PHLDB1/2/3, PH domain
Family	IPR052212	Pleckstrin homology-like domain-containing protein
Homologous_superfamily	IPR008984	SMAD/FHA domain superfamily
Homologous_superfamily	IPR011993	PH-like domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M9Q9E5	InterPro	1424
UniProtKB:A0A8M9PL23	InterPro	1382
UniProtKB:A0A8M3ASG1	InterPro	1226
UniProtKB:A0A8M9Q464	InterPro	1334
UniProtKB:A0A8M3B9Q8	InterPro	1417
UniProtKB:A0A8M3ASK7	InterPro	1385
UniProtKB:A0A8M3B2L8	InterPro	1294
UniProtKB:A0A8N7TEA5	InterPro	1425
UniProtKB:A0A2R8QUX6	InterPro	1290
UniProtKB:A0A8M9PYP5	InterPro	1374
UniProtKB:A0AB32TV38	InterPro	1405
UniProtKB:A0AB32TVY0	InterPro	1246
UniProtKB:A0AC58JPA4	InterPro	1341
UniProtKB:A0AC58JPB6	InterPro	1249
UniProtKB:A0AC58JPB7	InterPro	1334
UniProtKB:A0AC58JPB8	InterPro	1381
UniProtKB:A0AC58JPB9	InterPro	1376
UniProtKB:A0AC58JPC1	InterPro	1293
UniProtKB:A0AC58JPC3	InterPro	1384
UniProtKB:A0AC58JPC4	InterPro	1361
UniProtKB:A0AC58JPC6	InterPro	1362
UniProtKB:A0AC58JPC7	InterPro	1404
UniProtKB:A0AC58JPC8	InterPro	1374
UniProtKB:A0AC58JPC9	InterPro	1356
UniProtKB:A0AC58JPD0	InterPro	1156
UniProtKB:A0AC58JPD1	InterPro	1242
UniProtKB:A0AC58JPD3	InterPro	1247
UniProtKB:A0AC58JPD4	InterPro	1286
UniProtKB:A0AC58JPD5	InterPro	1206
UniProtKB:A0AC58JPD6	InterPro	1333
UniProtKB:A0AC58JPD7	InterPro	1377
UniProtKB:A0AC58JPD8	InterPro	1251
UniProtKB:A0AC58JPD9	InterPro	1246
UniProtKB:A0AC58JPE0	InterPro	1285
UniProtKB:A0AC58JPE1	InterPro	1282
UniProtKB:A0AC58JPE4	InterPro	1198
UniProtKB:A0AC58JPE5	InterPro	1325
UniProtKB:A0AC58JPE8	InterPro	1182
UniProtKB:A0AC58JPE9	InterPro	1243
UniProtKB:A0AC58JPF0	InterPro	1174
UniProtKB:A0AC58JPF1	InterPro	1250
UniProtKB:A0AC58JPF2	InterPro	1207
UniProtKB:A0AC58JPF3	InterPro	1175
UniProtKB:A0AC58JPF5	InterPro	1199
UniProtKB:A0AC58JPF7	InterPro	1330
UniProtKB:A0AC58JPF9	InterPro	1342
UniProtKB:A0AC58JPG0	InterPro	1195
UniProtKB:A0AC58JPG4	InterPro	1218
UniProtKB:A0AC58JPG5	InterPro	1158
UniProtKB:A0AC58JPH2	InterPro	1250
UniProtKB:A0AC58JPH5	InterPro	1217
UniProtKB:A0AC58JPI1	InterPro	1116
UniProtKB:A0AC58JPI7	InterPro	1159
UniProtKB:A0AC58JPJ1	InterPro	1115

Transcripts

Genome Browsers

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	phldb1a-201 (1) Ensembl	Ensembl	3,725 nt	Select Tool ZFIN BLAST
mRNA	phldb1a-202 (1) Ensembl	Ensembl	4,244 nt	Select Tool ZFIN BLAST
mRNA	phldb1a-203 (1) Ensembl	Ensembl	5,123 nt	Select Tool ZFIN BLAST
mRNA	phldb1a-204 (1) Ensembl	Ensembl	4,511 nt	Select Tool ZFIN BLAST
mRNA	phldb1a-205 (1) Ensembl	Ensembl	5,252 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI Map Viewer

ZFIN

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations