Gene
slc4a4a
- ID
- ZDB-GENE-060526-274
- Name
- solute carrier family 4 member 4a
- Symbol
- slc4a4a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Enables sodium:bicarbonate symporter activity. Predicted to be involved in bicarbonate transport; regulation of intracellular pH; and transmembrane transport. Predicted to be located in membrane. Predicted to be active in basolateral plasma membrane. Is expressed in several structures, including central nervous system; eye; intermediate mesoderm; optic cup; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in renal tubular acidosis. Orthologous to human SLC4A4 (solute carrier family 4 member 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 24 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Sussman et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Proximal renal tubular acidosis-ocular anomaly syndrome | 604278 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR011531 | Bicarbonate transporter-like, transmembrane domain |
| Domain | IPR013769 | Band 3 cytoplasmic domain |
| Family | IPR003020 | Bicarbonate transporter, eukaryotic |
| Family | IPR003024 | Sodium bicarbonate cotransporter |
| Homologous_superfamily | IPR016152 | Phosphotransferase/anion transporter |
Domain Details Per Protein
| Protein | Additional Resources | Length | Band 3 cytoplasmic domain | Bicarbonate transporter, eukaryotic | Bicarbonate transporter-like, transmembrane domain | Phosphotransferase/anion transporter | Sodium bicarbonate cotransporter |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q3ZMH2 | InterPro | 1082 | |||||
| UniProtKB:A0A2R8QD45 | InterPro | 1073 | |||||
| UniProtKB:A0A8M3ASQ6 | InterPro | 1146 | |||||
| UniProtKB:A0A8M3B2R8 | InterPro | 1114 | |||||
| UniProtKB:A0A8M3AZV9 | InterPro | 1105 | |||||
| UniProtKB:A0A8M9Q3P6 | InterPro | 1114 | |||||
| UniProtKB:A0AB32TPR4 | InterPro | 1089 | |||||
| UniProtKB:A0AB32TTV9 | InterPro | 1098 | |||||
| UniProtKB:A0AB32TVF5 | InterPro | 1130 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc4a4a-201
(1)
|
Ensembl | 6,227 nt | ||
| mRNA |
slc4a4a-202
(1)
|
Ensembl | 2,810 nt | ||
| mRNA |
slc4a4a-205
(1)
|
Ensembl | 6,323 nt | ||
| mRNA |
slc4a4a-206
(1)
|
Ensembl | 3,417 nt | ||
| ncRNA |
slc4a4a-002
(1)
|
Ensembl | 499 nt | ||
| ncRNA |
slc4a4a-003
(1)
|
Ensembl | 542 nt |
Interactions and Pathways
No data available
Plasmids
No data available