dnah10

ID

ZDB-GENE-060531-163

Name

dynein axonemal heavy chain 10

Symbol

dnah10 Nomenclature History

Previous Names

si:dkeyp-86b9.1

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Acts upstream of or within cilium movement and determination of left/right symmetry. Predicted to be located in cytoplasm and microtubule. Predicted to be part of dynein complex. Predicted to be active in 9+2 motile cilium. Is expressed in notochord. Used to study idiopathic scoliosis. Human ortholog(s) of this gene implicated in spermatogenic failure 56. Orthologous to human DNAH10 (dynein axonemal heavy chain 10).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Liu et al., 2018

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dnah10 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
spermatogenic failure 56	Alliance	Spermatogenic failure 56	619515

Associated With dnah10 Via Experimental Models

Human Disease	Fish	Conditions	Citations
idiopathic scoliosis	AB + CRISPR2-dnah10 + CRISPR3-dnah10 + CRISPR4-dnah10 + CRISPR5-dnah10	standard conditions	Wang et al., 2021
idiopathic scoliosis	dnah10^ut28/ut28 (AB)	standard conditions	Wang et al., 2021
idiopathic scoliosis	dnah10^ut28/ut28 (AB)	standard conditions	Wang et al., 2021
idiopathic scoliosis	dnah10^ut28/ut28 (AB)	standard conditions	Wang et al., 2021

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR004273	Dynein heavy chain region D6 P-loop domain
Domain	IPR013594	Dynein heavy chain, tail
Domain	IPR013602	Dynein heavy chain, linker
Domain	IPR024317	Dynein heavy chain, AAA module D4
Domain	IPR024743	Dynein heavy chain, coiled coil stalk
Domain	IPR035699	Dynein heavy chain, hydrolytic ATP-binding dynein motor region
Domain	IPR035706	Dynein heavy chain, ATP-binding dynein motor region
Domain	IPR041228	Dynein heavy chain, C-terminal domain
Domain	IPR041466	Dynein heavy chain, AAA 5 extension domain
Domain	IPR041658	Dynein heavy chain AAA lid domain
Domain	IPR054354	Dynein 2 heavy chain 1, cytoplasmic, ATPase lid domain
Family	IPR026983	Dynein heavy chain
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR042219	Dynein heavy chain AAA lid domain superfamily
Homologous_superfamily	IPR042222	Dynein heavy chain, domain 2, N-terminal
Homologous_superfamily	IPR042228	Dynein heavy chain, linker, subdomain 3
Homologous_superfamily	IPR043157	Dynein heavy chain, AAA1 domain, small subdomain
Homologous_superfamily	IPR043160	Dynein heavy chain, C-terminal domain, barrel region