card9

ID

ZDB-GENE-060531-94

Name

caspase recruitment domain family, member 9

Symbol

card9 Nomenclature History

Previous Names

si:dkey-1o2.6

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable signaling adaptor activity. Predicted to be involved in positive regulation of canonical NF-kappaB signal transduction; regulation of immune response; and signal transduction. Predicted to act upstream of or within regulation of apoptotic process. Predicted to be part of CBM complex. Predicted to be active in cytoplasm. Is expressed in brain; gill; liver; pleuroperitoneal region; and unfertilized egg. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human CARD9 (caspase recruitment domain family member 9).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With card9 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
chronic mucocutaneous candidiasis	Alliance	Immunodeficiency 103, susceptibility to fungal infection	212050

Associated With card9 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001315	CARD domain
Domain	IPR042142	CARD9, CARD domain
Homologous_superfamily	IPR011029	Death-like domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M3AZX7	InterPro	521
UniProtKB:A0A8M3B9W3	InterPro	568
UniProtKB:A0A8M3B2T4	InterPro	556
UniProtKB:A0A8M2BD15	InterPro	557
UniProtKB:A2CE85	InterPro	534
UniProtKB:A0A8M3ASS5	InterPro	566
UniProtKB:A0A8M3ASN6	InterPro	577
UniProtKB:A0AC58JL77	InterPro	536