ZFIN is now using GRCz12tu for Genomic Data
Gene
clcn4
- ID
- ZDB-GENE-061013-353
- Name
- Cl-/H+ antiporter 4
- Symbol
- clcn4 Nomenclature History
- Previous Names
-
- zgc:153764
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable voltage-gated chloride channel activity. Predicted to act upstream of or within chloride transport and transmembrane transport. Predicted to be located in endosome and membrane. Predicted to be active in several cellular components, including cytoplasmic vesicle; endoplasmic reticulum membrane; and lysosomal membrane. Is expressed in brain; eye; gill; heart; and immune system. Human ortholog(s) of this gene implicated in Raynaud-Claes syndrome. Orthologous to human CLCN4 (Cl-/H+ antiporter 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Wang et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Raynaud-Claes syndrome | Alliance | Raynaud-Claes syndrome | 300114 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CBS domain | CBS domain superfamily | Chloride channel | Chloride channel ClC-4 | Chloride channel, core |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q08BG8 | InterPro | 768 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers