e2f3

ID

ZDB-GENE-070112-882

Name

E2F transcription factor 3

Symbol

e2f3 Nomenclature History

Previous Names

wu:fc51d01
zgc:158604

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in brain; liver; and telencephalon. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and prostate cancer. Orthologous to human E2F3 (E2F transcription factor 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With e2f3 Human Ortholog

No data available

Associated With e2f3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Domain	IPR032198	E2F transcription factor, CC-MB domain
Family	IPR015633	E2F Family
Homologous_superfamily	IPR036388	Winged helix-like DNA-binding domain superfamily
Homologous_superfamily	IPR036390	Winged helix DNA-binding domain superfamily
Homologous_superfamily	IPR037241	E2F-DP heterodimerization region