Gene

nrxn1a

ID

ZDB-GENE-070206-1

Name

neurexin 1a

Symbol

nrxn1a Nomenclature History

Previous Names

nrxn1aa
nrxn1ab

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to enable metal ion binding activity. Acts upstream of or within sprouting angiogenesis. Predicted to be located in membrane. Is expressed in caudal vein plexus; diencephalon; hindbrain; spinal cord; and telencephalon. Human ortholog(s) of this gene implicated in Pitt-Hopkins-like syndrome 2. Orthologous to human NRXN1 (neurexin 1).

Genome Resources

Note

nrxn1a has two isoforms, alpha (DQ641424) and beta (DQ641425)

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Rissone et al., 2012
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nrxn1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Pitt-Hopkins-like syndrome 2	Alliance	Pitt-Hopkins-like syndrome 2	614325
		{Schizophrenia, susceptibility to, 17}	614332

Associated With nrxn1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000742	EGF-like domain
Domain	IPR001791	Laminin G domain
Domain	IPR003585	Neurexin/syndecan/glycophorin C
Domain	IPR027789	Syndecan/Neurexin domain
Family	IPR050372	Neurexin-related cell adhesion and synaptic protein
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A2R8QKE7	InterPro	1481
UniProtKB:A1XQX1	InterPro	449
UniProtKB:A0A8M3B4L1	InterPro	1491
UniProtKB:A0A8M3BE54	InterPro	1488
UniProtKB:A0A8M3AYC5	InterPro	1489
UniProtKB:A0A8M3AYD0	InterPro	1454
UniProtKB:A0A8M3B7E0	InterPro	1492
UniProtKB:A0A8M9QIT8	InterPro	1445
UniProtKB:A0A8M3BE57	InterPro	1451
UniProtKB:A0A8M2B276	InterPro	1488
UniProtKB:A0A8M9QED3	InterPro	1475
UniProtKB:A0A8M3B7E5	InterPro	1467
UniProtKB:A0A8M9Q8I0	InterPro	1477
UniProtKB:A0A8M9QIT3	InterPro	1487
UniProtKB:A0A8M3B4L5	InterPro	1464
UniProtKB:A0A8M3B7D6	InterPro	1497
UniProtKB:A1XQX0	InterPro	1491
UniProtKB:A0A8M3B4K7	InterPro	1496
UniProtKB:A0A140TAU1	InterPro	1484
UniProtKB:A0A8M9QML2	InterPro	1414
UniProtKB:A0A8M3AY99	InterPro	1493
UniProtKB:A0A8M3BE52	InterPro	1493
UniProtKB:A0A8M9QIU1	InterPro	1422
UniProtKB:A0A8M9QED6	InterPro	1455
UniProtKB:A0A8M9Q8I6	InterPro	1471
UniProtKB:A0A8M9QML0	InterPro	1472
UniProtKB:A0A8M9PWG1	InterPro	1417
UniProtKB:B6EUL5	InterPro	419
UniProtKB:A0A8M3AYC2	InterPro	1494
UniProtKB:A0AB32TY39	InterPro	1501
UniProtKB:A0AB32TY45	InterPro	1503
UniProtKB:A0AB32TY52	InterPro	1442
UniProtKB:A0AB32TY59	InterPro	1458
UniProtKB:A0AB32TYS1	InterPro	1498
UniProtKB:A0AB32U0B7	InterPro	1499
UniProtKB:A0AB32U0D2	InterPro	1429
UniProtKB:A0AB32U0F2	InterPro	1494
UniProtKB:A0AB32U0W8	InterPro	1495
UniProtKB:A0AB32U196	InterPro	1488
UniProtKB:A0AB32U1F7	InterPro	1500
UniProtKB:A0AB32U1G9	InterPro	1432
UniProtKB:A0AB32U2Q2	InterPro	1500
UniProtKB:A0AB32U2R6	InterPro	1478
UniProtKB:A0AB32U341	InterPro	1484
UniProtKB:A0AB32U3E0	InterPro	1462
UniProtKB:A0AB32U455	InterPro	1474
UniProtKB:A0AB32U4B4	InterPro	1495
UniProtKB:A0AB32U4C4	InterPro	1504
UniProtKB:A0AB32U4D9	InterPro	1461
UniProtKB:A0AB32U585	InterPro	1471

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	nrxn1a-201 (1) Ensembl	Ensembl	1,425 nt	Select Tool ZFIN BLAST
mRNA	nrxn1a-202 (1) Ensembl	Ensembl	3,069 nt	Select Tool ZFIN BLAST
mRNA	nrxn1a-203 (1) Ensembl	Ensembl	9,670 nt	Select Tool ZFIN BLAST
mRNA	nrxn1a-204 (1) Ensembl	Ensembl	7,007 nt	Select Tool ZFIN BLAST
mRNA	nrxn1a-205 (1) Ensembl	Ensembl	6,457 nt	Select Tool ZFIN BLAST
mRNA	nrxn1a-207 (1) Ensembl	Ensembl	9,643 nt	Select Tool ZFIN BLAST
mRNA	nrxn1a-208 (1) Ensembl	Ensembl	9,682 nt	Select Tool ZFIN BLAST
mRNA	nrxn1a-209 (1) Ensembl	Ensembl	9,649 nt	Select Tool ZFIN BLAST
ncRNA	nrxn1a-004 (1) Ensembl	Ensembl	906 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations