ZFIN is now using GRCz12tu for Genomic Data
Gene
nrxn1a
- ID
- ZDB-GENE-070206-1
- Name
- neurexin 1a
- Symbol
- nrxn1a Nomenclature History
- Previous Names
-
- nrxn1aa
- nrxn1ab
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable neuroligin family protein binding activity and transmembrane signaling receptor activity. Acts upstream of or within sprouting angiogenesis. Predicted to be located in membrane. Predicted to be part of trans-synaptic protein complex. Predicted to be active in presynaptic active zone membrane. Is expressed in caudal vein plexus; diencephalon; hindbrain; spinal cord; and telencephalon. Human ortholog(s) of this gene implicated in Pitt-Hopkins-like syndrome 2. Orthologous to human NRXN1 (neurexin 1).
- Genome Resources
- Note
-
nrxn1a has two isoforms, alpha (DQ641424) and beta (DQ641425)
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Rissone et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Pitt-Hopkins-like syndrome 2 | Alliance | Pitt-Hopkins-like syndrome 2 | 614325 |
| {Schizophrenia, susceptibility to, 17} | 621407 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001791 | Laminin G domain |
| Domain | IPR003585 | Neurexin/syndecan/glycophorin C |
| Domain | IPR027789 | Syndecan/Neurexin domain |
| Family | IPR050372 | Neurexin-related cell adhesion and synaptic protein |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
Domain Details Per Protein
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nrxn1a-201
(1)
|
Ensembl | 1,425 nt | ||
| mRNA |
nrxn1a-202
(1)
|
Ensembl | 3,069 nt | ||
| mRNA |
nrxn1a-203
(1)
|
Ensembl | 9,670 nt | ||
| mRNA |
nrxn1a-204
(1)
|
Ensembl | 7,007 nt | ||
| mRNA |
nrxn1a-205
(1)
|
Ensembl | 6,457 nt | ||
| mRNA |
nrxn1a-207
(1)
|
Ensembl | 9,643 nt | ||
| mRNA |
nrxn1a-208
(1)
|
Ensembl | 9,682 nt | ||
| mRNA |
nrxn1a-209
(1)
|
Ensembl | 9,649 nt | ||
| ncRNA |
nrxn1a-004
(1)
|
Ensembl | 906 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers