ZFIN is now using GRCz12tu for Genomic Data

Gene

cfap45

ID

ZDB-GENE-070209-143

Name

cilia and flagella associated protein 45

Symbol

cfap45 Nomenclature History

Previous Names

ccdc19
fc64b08
wu:fc64b08
zgc:158569 (1)

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable small GTPase binding activity. Predicted to act upstream of or within intracellular protein transport. Predicted to be located in motile cilium. Is expressed in forerunner cell group. Human ortholog(s) of this gene implicated in visceral heterotaxy 11. Orthologous to human CFAP45 (cilia and flagella associated protein 45).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Fillatre et al., 2019

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cfap45 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
visceral heterotaxy 11	Alliance	Heterotaxy, visceral, 11, autosomal, with male infertility	619608

Associated With cfap45 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR010911	Rab-binding domain
Domain	IPR043597	Trichohyalin-plectin-homology domain
Family	IPR033253	Cilia- and flagella-associated protein 45

Domain Details Per Protein

Protein	Additional Resources	Length	Cilia- and flagella-associated protein 45	Rab-binding domain	Trichohyalin-plectin-homology domain
UniProtKB:A0A8M1NCB7	InterPro	543
UniProtKB:A2RV04	InterPro	497

Transcripts

Genome Browsers

NCBI Map Viewer

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cfap45-201 (1) Ensembl	Ensembl	1,862 nt	Select Tool ZFIN BLAST
mRNA	cfap45-204 (1) Ensembl	Ensembl	1,220 nt	Select Tool ZFIN BLAST
mRNA	cfap45-205 (1) Ensembl	Ensembl	3,668 nt	Select Tool ZFIN BLAST
ncRNA	cfap45-002 (1) Ensembl	Ensembl	1,293 nt	Select Tool ZFIN BLAST
ncRNA	cfap45-003 (1) Ensembl	Ensembl	824 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI Map Viewer

ZFIN

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations