fsd1l

ID

ZDB-GENE-070501-9

Name

fibronectin type III and SPRY domain containing 1 like

Symbol

fsd1l Nomenclature History

Previous Names

sb:eu990

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Is expressed in otic vesicle. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with seizures, spastic tetraparesis, and vision impairment and retinitis pigmentosa. Orthologous to human FSD1L (fibronectin type III and SPRY domain containing 1 like).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu990 (4 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fsd1l Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
neurodevelopmental disorder with seizures, spastic tetraparesis, and vision impairment	Alliance	Neurodevelopmental disorder with seizures, spastic tetraparesis, and vision impairment	621643
		Retinitis pigmentosa 109	621656

Associated With fsd1l Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001870	B30.2/SPRY domain
Domain	IPR003649	B-box, C-terminal
Domain	IPR003877	SPRY domain
Domain	IPR003879	Butyrophylin-like, SPRY domain
Domain	IPR003961	Fibronectin type III
Domain	IPR017903	COS domain
Domain	IPR035742	Fibronectin type III and SPRY containing 1, PRY/SPRY domain
Family	IPR050617	E3 ubiquitin-protein ligases and FN3/SPRY domain-containing proteins
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036116	Fibronectin type III superfamily
Homologous_superfamily	IPR043136	B30.2/SPRY domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M2BFY7	InterPro	530
UniProtKB:A0A8M9P927	InterPro	476
UniProtKB:A0A8M3BA30	InterPro	529
UniProtKB:A0A8M9PK71	InterPro	465
UniProtKB:A0A8M9PR76	InterPro	461
UniProtKB:A0A8M9PZ93	InterPro	518
UniProtKB:A0A8M9PLN4	InterPro	519
UniProtKB:A0A8M9Q1V1	InterPro	367
UniProtKB:A0A8M9PYH3	InterPro	477
UniProtKB:A0A8M9Q512	InterPro	420
UniProtKB:A0A8M2BFZ8	InterPro	518
UniProtKB:A0A8M9Q9Y0	InterPro	529
UniProtKB:A0A8M1PUU5	InterPro	519
UniProtKB:A0A8M9PEX5	InterPro	420
UniProtKB:A0A8M9QEZ5	InterPro	530
UniProtKB:A0AB13A7C6	InterPro	530
UniProtKB:A0AC58JGS1	InterPro	409
UniProtKB:A0AC58JGS5	InterPro	420
UniProtKB:A0AC58JGS9	InterPro	408