ZFIN is now using GRCz12tu for Genomic Data
Gene
cyp7b1
- ID
- ZDB-GENE-070912-293
- Name
- cytochrome P450, family 7, subfamily B, polypeptide 1
- Symbol
- cyp7b1 Nomenclature History
- Previous Names
-
- cyp7c1
- si:ch211-39l18.4
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable steroid hydroxylase activity. Predicted to be involved in bile acid biosynthetic process and cholesterol homeostasis. Human ortholog(s) of this gene implicated in congenital bile acid synthesis defect 3 and hereditary spastic paraplegia 5A. Orthologous to human CYP7B1 (cytochrome P450 family 7 subfamily B member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital bile acid synthesis defect 3 | Alliance | Bile acid synthesis defect, congenital, 3 | 613812 |
| hereditary spastic paraplegia 5A | Alliance | Spastic paraplegia 5A, autosomal recessive | 270800 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017972 | Cytochrome P450, conserved site |
| Family | IPR001128 | Cytochrome P450 |
| Family | IPR002403 | Cytochrome P450, E-class, group IV |
| Family | IPR024204 | Cytochrome P450, cholesterol 7-alpha-monooxygenase-type |
| Family | IPR050529 | Lanosterol 14-alpha demethylase-like |
| Homologous_superfamily | IPR036396 | Cytochrome P450 superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Cytochrome P450 | Cytochrome P450, cholesterol 7-alpha-monooxygenase-type | Cytochrome P450, conserved site | Cytochrome P450, E-class, group IV | Cytochrome P450 superfamily | Lanosterol 14-alpha demethylase-like |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7FEI0 | InterPro | 504 | ||||||
| UniProtKB:A0ACD6B5U4 | InterPro | 504 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyp7b1-201
(1)
|
Ensembl | 1,707 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers