ZFIN is now using GRCz12tu for Genomic Data
Gene
igf2bp2a
- ID
- ZDB-GENE-070912-44
- Name
- insulin-like growth factor 2 mRNA binding protein 2a
- Symbol
- igf2bp2a Nomenclature History
- Previous Names
-
- igf2bp2
- si:ch211-125m20.1
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in CRD-mediated mRNA stabilization and nervous system development. Predicted to act upstream of or within mRNA transport and regulation of translation. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IGF2BP2 (insulin like growth factor 2 mRNA binding protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from O'Hare et al., 2016
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| type 2 diabetes mellitus | Alliance | {Diabetes mellitus, noninsulin-dependent, susceptibility to} | 125853 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000504 | RNA recognition motif domain |
| Domain | IPR004087 | K Homology domain |
| Domain | IPR004088 | K Homology domain, type 1 |
| Domain | IPR034843 | IGF2BP2, RNA recognition motif 1 |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
| Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
| Homologous_superfamily | IPR036612 | K Homology domain, type 1 superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | IGF2BP2, RNA recognition motif 1 | K Homology domain | K Homology domain, type 1 | K Homology domain, type 1 superfamily | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | RNA recognition motif domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A9C3V8 | InterPro | 606 | |||||||
| UniProtKB:A0A0B4J1B0 | InterPro | 607 | |||||||
| UniProtKB:A0A2R8RHK1 | InterPro | 453 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
igf2bp2a-201
(1)
|
Ensembl | 2,707 nt | ||
| mRNA |
igf2bp2a-202
(1)
|
Ensembl | 2,405 nt | ||
| mRNA |
igf2bp2a-203
(1)
|
Ensembl | 1,827 nt | ||
| mRNA |
igf2bp2a-204
(1)
|
Ensembl | 1,912 nt | ||
| mRNA |
igf2bp2a-205
(1)
|
Ensembl | 2,101 nt | ||
| mRNA |
igf2bp2a-206
(1)
|
Ensembl | 1,608 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers