ZFIN is now using GRCz12tu for Genomic Data
Gene
zeb2a
- ID
- ZDB-GENE-070912-553
- Name
- zinc finger E-box binding homeobox 2a
- Symbol
- zeb2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including chordate embryonic development; convergent extension; and negative regulation of fibroblast growth factor receptor signaling pathway. Predicted to be active in nucleus. Is expressed in several structures, including head; nervous system; neural plate; neuroectoderm; and tail bud. Human ortholog(s) of this gene implicated in Hirschsprung's disease and Mowat-Wilson syndrome. Orthologous to human ZEB2 (zinc finger E-box binding homeobox 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu412 (26 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Mowat-Wilson syndrome | Alliance | Mowat-Wilson syndrome | 235730 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Zinc finger C2H2 superfamily | Zinc finger C2H2-type | Zinc finger E-box-binding homeobox |
|---|---|---|---|---|---|
| UniProtKB:B5DE38 | InterPro | 1175 | |||
| UniProtKB:F1QY45 | InterPro | 1218 | |||
| UniProtKB:A0A8M9Q4G0 | InterPro | 1095 | |||
| UniProtKB:B0LVE9 | InterPro | 1201 | |||
| UniProtKB:A0A8M2BFJ5 | InterPro | 1192 | |||
| UniProtKB:A0AC58GCP6 | InterPro | 1242 | |||
| UniProtKB:A0AC58GCP7 | InterPro | 1242 | |||
| UniProtKB:A0AC58GCP8 | InterPro | 1242 | |||
| UniProtKB:A0AC58GCP9 | InterPro | 1192 | |||
| UniProtKB:A0AC58GCQ2 | InterPro | 1216 | |||
| UniProtKB:A0AC58GCQ3 | InterPro | 1218 | |||
| UniProtKB:A0AC58GCQ6 | InterPro | 1242 | |||
| UniProtKB:A0AC58GCQ7 | InterPro | 1218 | |||
| UniProtKB:A0AC58GCR0 | InterPro | 1192 | |||
| UniProtKB:A0AC58GCR2 | InterPro | 1192 | |||
| UniProtKB:A0AC58GCR3 | InterPro | 1095 | |||
| UniProtKB:A0AC58GCR5 | InterPro | 1192 | |||
| UniProtKB:A0AC58GCR7 | InterPro | 1216 | |||
| UniProtKB:A0AC58GCR8 | InterPro | 1216 | |||
| UniProtKB:A0AC58GCR9 | InterPro | 1069 | |||
| UniProtKB:A0AC58GCS0 | InterPro | 1192 | |||
| UniProtKB:A0AC58GCS3 | InterPro | 1218 | |||
| UniProtKB:A0AC58GCS6 | InterPro | 1216 | |||
| UniProtKB:A0AC58GCT1 | InterPro | 1218 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
zeb2a-201
(1)
|
Ensembl | 4,058 nt | ||
| mRNA |
zeb2a-202
(1)
|
Ensembl | 1,351 nt | ||
| mRNA |
zeb2a-203
(1)
|
Ensembl | 448 nt | ||
| mRNA |
zeb2a-204
(1)
|
Ensembl | 859 nt | ||
| mRNA |
zeb2a-206
(1)
|
Ensembl | 4,250 nt | ||
| mRNA |
zeb2a-207
(1)
|
Ensembl | 3,606 nt | ||
| mRNA |
zeb2a-208
(1)
|
Ensembl | 5,237 nt | ||
| ncRNA |
zeb2a-004
(1)
|
Ensembl | 940 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers