ZFIN is now using GRCz12tu for Genomic Data
Gene
pax7b
- ID
- ZDB-GENE-080917-54
- Name
- paired box 7b
- Symbol
- pax7b Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in nervous system development and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including brain; hindbrain neural rod; neural crest cell; pigment cell; and trunk. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma and congenital myopathy 19. Orthologous to human PAX7 (paired box 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Nord et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| alveolar rhabdomyosarcoma | Alliance | Rhabdomyosarcoma 2, alveolar | 268220 |
| congenital myopathy 19 | Alliance | Congenital myopathy 19 | 618578 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017970 | Homeobox, conserved site |
| Conserved_site | IPR043182 | Paired DNA-binding site |
| Domain | IPR001356 | Homeodomain |
| Domain | IPR001523 | Paired domain |
| Domain | IPR003654 | OAR domain |
| Domain | IPR022106 | Paired box protein 7, C-terminal |
| Family | IPR043565 | PAX family |
| Homologous_superfamily | IPR009057 | Homedomain-like superfamily |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | OAR domain | Paired box protein 7, C-terminal | Paired DNA-binding site | Paired domain | PAX family | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:C0M005 | InterPro | 510 | |||||||||
| UniProtKB:A0AB32TBV6 | InterPro | 501 | |||||||||
| UniProtKB:A0AB40E8R2 | InterPro | 506 | |||||||||
| UniProtKB:A0AC58IKH0 | InterPro | 520 | |||||||||
| UniProtKB:A0AC58IKH7 | InterPro | 515 | |||||||||
| UniProtKB:A0AC58IKK3 | InterPro | 506 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers