ZFIN is now using GRCz12tu for Genomic Data

Gene

dynlt2b

ID

ZDB-GENE-081104-219

Name

dynein light chain Tctex-type 2B

Symbol

dynlt2b Nomenclature History

Previous Names

si:ch211-276k2.4 (1)
tctex1d2

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in intraciliary retrograde transport. Predicted to be located in dynein axonemal particle. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in cytoplasm. Used to study ciliopathy. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy. Orthologous to human DYNLT2B (dynein light chain Tctex-type 2B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Schmidts et al., 2015
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dynlt2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Short-rib thoracic dysplasia 17 with or without polydactyly	617405

Associated With dynlt2b Via Experimental Models

Human Disease	Fish	Conditions	Citations
ciliopathy	WT + MO1-dynlt2b + MO4-tp53	standard conditions	Schmidts et al., 2015

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR005334	Dynein light chain Tctex-1 like
Homologous_superfamily	IPR038586	Tctex-1-like superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	Dynein light chain Tctex-1 like	Tctex-1-like superfamily
UniProtKB:F1QMY1	InterPro	150
UniProtKB:A0AB13ABI5	InterPro	150

Transcripts

Genome Browsers

NCBI Map Viewer

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	tctex1d2-201 (1) Ensembl	Ensembl		958 nt	Select Tool ZFIN BLAST
mRNA	tctex1d2-202 (1) Ensembl	Ensembl		489 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI Map Viewer

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations