ZFIN is now using GRCz12tu for Genomic Data
Gene
pde4d
- ID
- ZDB-GENE-081105-16
- Name
- phosphodiesterase 4D, cAMP-specific
- Symbol
- pde4d Nomenclature History
- Previous Names
-
- si:dkey-190g11.2
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Predicted to be involved in negative regulation of cAMP/PKA signal transduction. Predicted to act upstream of or within signal transduction. Is expressed in brain; female organism; and head. Human ortholog(s) of this gene implicated in acrodysostosis; asthma; chronic obstructive pulmonary disease; and stroke. Orthologous to human PDE4D (phosphodiesterase 4D).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acrodysostosis | Alliance | Acrodysostosis 2, with or without hormone resistance | 614613 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR023174 | 3'5'-cyclic nucleotide phosphodiesterase, conserved site |
| Domain | IPR002073 | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain |
| Domain | IPR003607 | HD/PDEase domain |
| Domain | IPR040844 | Phosphodiesterase 4 upstream conserved regions (UCR) |
| Family | IPR023088 | 3'5'-cyclic nucleotide phosphodiesterase |
| Homologous_superfamily | IPR036971 | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily |
Domain Details Per Protein
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers