ZFIN is now using GRCz12tu for Genomic Data
Gene
npnta
- ID
- ZDB-GENE-090312-201
- Name
- nephronectin a
- Symbol
- npnta Nomenclature History
- Previous Names
-
- npnt
- si:ch211-202n8.2
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable calcium ion binding activity and integrin binding activity. Acts upstream of or within heart development; pronephric glomerulus morphogenesis; and regulation of glomerular filtration. Predicted to be located in extracellular region and membrane. Is expressed in several structures, including digestive system; endoderm; head; heart; and tail bud. Used to study membranous glomerulonephritis and proteinuria. Orthologous to human NPNT (nephronectin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| proteinuria | WT + MO2-npnta | standard conditions | Müller-Deile et al., 2017 |
| membranous glomerulonephritis | WT + MO2-npnta | standard conditions | Müller-Deile et al., 2017 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR000998 | MAM domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR024731 | NELL2-like, EGF domain |
| Domain | IPR049883 | NOTCH1, EGF-like calcium-binding domain |
| Family | IPR052235 | Nephronectin domain-containing protein |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
Domain Details Per Protein
| Protein | Additional Resources | Length | Concanavalin A-like lectin/glucanase domain superfamily | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | MAM domain | NELL2-like, EGF domain | Nephronectin domain-containing protein | NOTCH1, EGF-like calcium-binding domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B6Z0 | InterPro | 619 | ||||||||||
| UniProtKB:A0A8M3AVI7 | InterPro | 588 | ||||||||||
| UniProtKB:B8A5G4 | InterPro | 605 | ||||||||||
| UniProtKB:A0A8M3B3H9 | InterPro | 636 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers