arfgef2

ID

ZDB-GENE-090312-50

Name

ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)

Symbol

arfgef2 Nomenclature History

Previous Names

si:dkey-192i18.4

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within with a positive effect on angioblast cell migration and cell migration involved in sprouting angiogenesis. Predicted to be located in Golgi apparatus. Is expressed in brain. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human ARFGEF2 (ARF guanine nucleotide exchange factor 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Lu et al., 2019

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Lu et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With arfgef2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
periventricular nodular heterotopia	Alliance	Periventricular heterotopia with microcephaly	608097

Associated With arfgef2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000904	Sec7 domain
Domain	IPR015403	Mon2/Sec7/BIG1-like, HDS
Domain	IPR032629	Mon2/Sec7/BIG1-like, dimerisation and cyclophilin-binding domain
Domain	IPR032691	Mon2/Sec7/BIG1-like, HUS domain
Domain	IPR046455	Sec7/BIG1-like, C-terminal domain
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR016024	Armadillo-type fold
Homologous_superfamily	IPR023394	Sec7, C-terminal domain superfamily
Homologous_superfamily	IPR035999	Sec7 domain superfamily