prss12

ID

ZDB-GENE-090313-45

Name

serine protease 12

Symbol

prss12 Nomenclature History

Previous Names

si:ch211-152j23.2

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable serine-type endopeptidase activity. Predicted to be involved in zymogen activation. Predicted to be active in several cellular components, including glutamatergic synapse; synaptic cleft; and terminal bouton. Is expressed in hypural. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 1 and intellectual disability. Orthologous to human PRSS12 (serine protease 12).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Anderson et al., 2020

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With prss12 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive intellectual developmental disorder 1	Alliance	Intellectual developmental disorder, autosomal recessive 1	249500

Associated With prss12 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

No data available

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M1QHD3	InterPro	818
UniProtKB:A0A8M9PPR7	InterPro	818
UniProtKB:A0A8M9Q8F7	InterPro	660
UniProtKB:A0AC58JJS7	InterPro	818
UniProtKB:A0AC58JJT2	InterPro	660