ZFIN is now using GRCz12tu for Genomic Data
Gene
srebf1
- ID
- ZDB-GENE-090812-3
- Name
- sterol regulatory element binding transcription factor 1
- Symbol
- srebf1 Nomenclature History
- Previous Names
-
- SREBP1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including pancreas regeneration; regulation of bone development; and type B pancreatic cell development. Predicted to be located in ER to Golgi transport vesicle membrane; Golgi membrane; and endoplasmic reticulum membrane. Predicted to be active in nucleus. Is expressed in female organism; intestine; liver; male organism; and ventral wall of dorsal aorta. Human ortholog(s) of this gene implicated in coronary artery disease; disease of metabolism; and type 2 diabetes mellitus. Orthologous to human SREBF1 (sterol regulatory element binding transcription factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 69 figures from 61 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain |
|---|---|---|---|---|
| UniProtKB:A6XLD8 | InterPro | 1105 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
srebf1-201
(1)
|
Ensembl | 2,826 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers