tcf4

ID

ZDB-GENE-090814-1

Name

transcription factor 4

Symbol

tcf4 Nomenclature History

Previous Names

tcf4l

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable DNA binding activity. Acts upstream of or within brain development and lens development in camera-type eye. Predicted to be located in nucleus. Is expressed in several structures, including brain; digestive system; notochord; pectoral fin bud; and retina. Used to study Pitt-Hopkins syndrome. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy; Lynch syndrome; and Pitt-Hopkins syndrome. Orthologous to human TCF4 (transcription factor 4).

Genome Resources

Alliance (1)
Gene:100526651 (1)

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 7 publications

Cross-Species Comparison

Alliance

High Throughput Data

Expression Atlas

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tcf4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Fuchs' endothelial dystrophy	Alliance	Corneal dystrophy, Fuchs endothelial, 3	613267
Pitt-Hopkins syndrome	Alliance	Pitt-Hopkins syndrome	610954

Associated With tcf4 Via Experimental Models

Human Disease	Fish	Conditions	Citations
Pitt-Hopkins syndrome	AB/TU + MO1-tcf4 + MO2-tcf4	standard conditions	Brockschmidt et al., 2011

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

No data available

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M9P3H6	InterPro	496
UniProtKB:A0AC58IBV8	InterPro	682
UniProtKB:A0AC58IBW2	InterPro	696
UniProtKB:A0AC58IBW4	InterPro	669
UniProtKB:A0AC58IBW6	InterPro	692
UniProtKB:A0AC58IBW7	InterPro	683
UniProtKB:A0AC58IBW8	InterPro	619
UniProtKB:A0AC58IBW9	InterPro	678
UniProtKB:A0AC58IBX0	InterPro	681
UniProtKB:A0AC58IBX1	InterPro	695
UniProtKB:A0AC58IBX2	InterPro	679
UniProtKB:A0AC58IBX3	InterPro	555
UniProtKB:A0AC58IBX4	InterPro	677
UniProtKB:A0AC58IBX5	InterPro	663
UniProtKB:A0AC58IBX6	InterPro	668
UniProtKB:A0AC58IBX7	InterPro	664
UniProtKB:A0AC58IBX8	InterPro	664
UniProtKB:A0AC58IBX9	InterPro	551
UniProtKB:A0AC58IBY0	InterPro	679
UniProtKB:A0AC58IBY1	InterPro	555
UniProtKB:A0AC58IBY2	InterPro	521
UniProtKB:A0AC58IBY3	InterPro	536
UniProtKB:A0AC58IBY5	InterPro	540
UniProtKB:A0AC58IBY6	InterPro	551
UniProtKB:A0AC58IBY7	InterPro	517
UniProtKB:A0AC58IBY9	InterPro	444
UniProtKB:A0AC58IBZ0	InterPro	506
UniProtKB:A0AC58IBZ6	InterPro	502