ZFIN is now using GRCz12tu for Genomic Data
Gene
kcnb1
- ID
- ZDB-GENE-090831-3
- Name
- potassium voltage-gated channel, Shab-related subfamily, member 1
- Symbol
- kcnb1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable potassium channel regulator activity. Acts upstream of or within epiboly and ventricular system development. Predicted to be located in several cellular components, including lateral plasma membrane; perikaryon; and sarcolemma. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Is expressed in central nervous system and otic vesicle. Used to study developmental and epileptic encephalopathy. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 26 and epilepsy. Orthologous to human KCNB1 (potassium voltage-gated channel subfamily B member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 26 | Alliance | Developmental and epileptic encephalopathy 26 | 616056 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| developmental and epileptic encephalopathy | kcnb1sq301/sq301 | standard conditions | Robichon et al., 2025 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000210 | BTB/POZ domain |
| Domain | IPR003131 | Potassium channel tetramerisation-type BTB domain |
| Domain | IPR005821 | Ion transport domain |
| Family | IPR003968 | Potassium channel, voltage dependent, Kv |
| Family | IPR003973 | Potassium channel, voltage dependent, Kv2 |
| Family | IPR004350 | Potassium channel, voltage dependent, Kv2.1 |
| Family | IPR028325 | Voltage-gated potassium channel |
| Homologous_superfamily | IPR011333 | SKP1/BTB/POZ domain superfamily |
| Homologous_superfamily | IPR027359 | Voltage-dependent channel domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | BTB/POZ domain | Ion transport domain | Potassium channel tetramerisation-type BTB domain | Potassium channel, voltage dependent, Kv | Potassium channel, voltage dependent, Kv2 | Potassium channel, voltage dependent, Kv2.1 | SKP1/BTB/POZ domain superfamily | Voltage-dependent channel domain superfamily | Voltage-gated potassium channel |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A2R8Q685 | InterPro | 834 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers