Gene

unc119a1

ID

ZDB-GENE-090930-2

Name

unc-119 lipid binding chaperone a1

Symbol

unc119a1 Nomenclature History

Previous Names

unc-119 (1)
Unc119 (1)
unc119a (1)
zfUnc119homA (1)
rtg4
si:dkey-234f12.7

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to enable lipid binding activity. Predicted to be involved in several processes, including lipoprotein transport; negative regulation of endocytosis; and visual perception. Predicted to act upstream of or within endocytosis and protein transport. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in intercellular bridge and microtubule cytoskeleton. Is expressed in several structures, including hematopoietic system; mesenchyme; olfactory pit; solid lens vesicle; and visual system. Human ortholog(s) of this gene implicated in cone-rod dystrophy 24 and immunodeficiency 13. Orthologous to human UNC119 (unc-119 lipid binding chaperone).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With unc119a1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
cone-rod dystrophy 24	Alliance	Cone-rod dystrophy 24	620342
immunodeficiency 13	Alliance	?Immunodeficiency 13	615518

Associated With unc119a1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR008015	GMP phosphodiesterase, delta subunit
Family	IPR051519	PDE6D/unc-119 myristoyl-binding
Homologous_superfamily	IPR014756	Immunoglobulin E-set
Homologous_superfamily	IPR037036	GMP phosphodiesterase, delta subunit superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	GMP phosphodiesterase, delta subunit	GMP phosphodiesterase, delta subunit superfamily	Immunoglobulin E-set	PDE6D/unc-119 myristoyl-binding
UniProtKB:F1QE32	InterPro	204

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	unc119a-201 (1) Ensembl	Ensembl	1,219 nt	Select Tool ZFIN BLAST
mRNA	unc119a-202 (1) Ensembl	Ensembl	603 nt	Select Tool ZFIN BLAST
mRNA	unc119a-203 (1) Ensembl	Ensembl	609 nt	Select Tool ZFIN BLAST
mRNA	unc119a-204 (1) Ensembl	Ensembl	402 nt	Select Tool ZFIN BLAST
mRNA	unc119a-205 (1) Ensembl	Ensembl	534 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations