ZFIN is now using GRCz12tu for Genomic Data
Gene
kcnt1a
- ID
- ZDB-GENE-091231-1
- Name
- potassium sodium-activated channel subfamily T member 1a
- Symbol
- kcnt1a Nomenclature History
- Previous Names
-
- kcnt1
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable intracellular sodium-activated potassium channel activity and outward rectifier potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be active in plasma membrane. Is expressed in midbrain; olfactory placode; peripheral olfactory organ; and tegmentum. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 5 and developmental and epileptic encephalopathy 14. Orthologous to human KCNT1 (potassium sodium-activated channel subfamily T member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Silic et al., 2021
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nocturnal frontal lobe epilepsy 5 | Alliance | Epilepsy nocturnal frontal lobe, 5 | 615005 |
| developmental and epileptic encephalopathy 14 | Alliance | Developmental and epileptic encephalopathy 14 | 614959 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003148 | Regulator of K+ conductance, N-terminal lobe |
| Domain | IPR003929 | Calcium-activated potassium channel BK, alpha subunit |
| Domain | IPR013099 | Potassium channel domain |
| Family | IPR047871 | Calcium-activated potassium channel slowpoke-like |
| Homologous_superfamily | IPR036291 | NAD(P)-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Calcium-activated potassium channel BK, alpha subunit | Calcium-activated potassium channel slowpoke-like | NAD(P)-binding domain superfamily | Potassium channel domain | Regulator of K+ conductance, N-terminal lobe |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3ALW9 | InterPro | 1173 | |||||
| UniProtKB:A0A8M3AWL0 | InterPro | 1172 | |||||
| UniProtKB:A0A8M3ATL3 | InterPro | 1159 | |||||
| UniProtKB:A0AB32TBQ1 | InterPro | 1230 | |||||
| UniProtKB:A0AB32TBZ7 | InterPro | 1217 | |||||
| UniProtKB:A0AB32TFH9 | InterPro | 1231 | |||||
| UniProtKB:A0AC58IC67 | InterPro | 1216 | |||||
| UniProtKB:A0AC58IC75 | InterPro | 1441 | |||||
| UniProtKB:A0AC58IC78 | InterPro | 1440 | |||||
| UniProtKB:A0AC58IC80 | InterPro | 1481 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kcnt1-206
(1)
|
Ensembl | 3,264 nt | ||
| mRNA |
kcnt1a-201
(1)
|
Ensembl | 3,169 nt | ||
| mRNA |
kcnt1a-202
(1)
|
Ensembl | 3,378 nt | ||
| mRNA |
kcnt1a-203
(1)
|
Ensembl | 3,360 nt | ||
| mRNA |
kcnt1a-204
(1)
|
Ensembl | 3,111 nt | ||
| mRNA |
kcnt1a-205
(1)
|
Ensembl | 3,336 nt |
Interactions and Pathways
No data available
Plasmids
- Genome Browsers