mmp21

ID

ZDB-GENE-100226-2

Name

matrix metallopeptidase 21

Symbol

mmp21 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable metalloendopeptidase activity. Acts upstream of or within determination of heart left/right asymmetry; embryonic heart tube left/right pattern formation; and regulation of heart looping. Predicted to be located in extracellular matrix. Is expressed in Kupffer's vesicle. Human ortholog(s) of this gene implicated in visceral heterotaxy 7. Orthologous to human MMP21 (matrix metallopeptidase 21).

Genome Resources

Note

XM_001342685 in ZDB-PUB-110131-35

Comparative Information

Expression

All Expression Data

2 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mmp21 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
visceral heterotaxy 7	Alliance	Heterotaxy, visceral, 7, autosomal	616749

Associated With mmp21 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001818	Peptidase M10, metallopeptidase
Domain	IPR002477	Peptidoglycan binding-like
Domain	IPR006026	Peptidase, metallopeptidase
Domain	IPR033739	Peptidase M10A, catalytic domain
Family	IPR021190	Peptidase M10A
Homologous_superfamily	IPR024079	Metallopeptidase, catalytic domain superfamily
Homologous_superfamily	IPR036365	PGBD-like superfamily
Homologous_superfamily	IPR036375	Hemopexin-like domain superfamily
Repeat	IPR018487	Hemopexin-like repeats